Definitive diagnosis of Craniosynostosis (CS) with computed tomography (CT) is readily available, however, exposure to ionizing radiation is often a hard stop for parents and practitioners. Lowering head CT radiation exposure helps mitigate risks and improves diagnostic utilization. The purpose of the study is to quantify radiation exposure from head CT in patients with CS using a ‘new’ (ultra-low dose) protocol; compare prior standard CT protocol; summarize published reports on cumulative radiation doses from pediatric head CT scans utilizing other low-dose protocols. A retrospective study was conducted on patients undergoing surgical correction of CS, aged less than 2 years, between August 2014 and February 2022. Cumulative effective dose (CED) in mSv was calculated, descriptive statistics were performed, and mean ± SD was reported. A literature search was conducted describing cumulative radiation exposure from head CT in pediatric patients and analyzed for ionizing radiation measurements. Forty-four patients met inclusion criteria: 17 females and 27 males. Patients who obtained head CT using the ‘New’ protocol resulted in lower CED exposure of 0.32 mSv ± 0.07 compared to the prior standard protocol at 5.25 mSv ± 2.79 (p < 0.0001). Five studies specifically investigated the reduction of ionizing radiation from CT scans in patients with CS via the utilization of low-dose CT protocols. These studies displayed overall CED values ranging from 0.015 mSv to 0.77 mSv. Our new CT protocol resulted in 94% reduction of ionizing radiation. Ultra-low dose CT protocols provide similar diagnostic data without loss of bone differentiation in CS and can be easily incorporated into the workflow of a children’s hospital.

Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

With the development and progress of the era, digital construction has become an important topic for enterprise development in the new era. Practice has shown that by actively carrying out corresponding digital construction work, enterprises can more comprehensively and systematically analyze the industry development and market prospects, which helps to promote the reasonable adjustment
of internal and external management work modes and the improvement of management efficiency, and has a positive guiding role for the healthy development cycle of enterprises. In this article, the author combines a large amount of research cases to conduct research on the effect of digital construction on enterprise development in the new era and proposes corresponding optimization measures, hoping to further promote the full play of information technology value, in order to safeguard the development of enterprises.

This study investigates the optimization of ride-sharing services (RSS) on the ride-hailing service (RHS) providers in Bangladesh. This study employed an explanatory sequential mixed method research design- a qualitative study followed by a quantitative one. Qualitative data were collected through focus group discussions and in-depth interviews with twenty (20) riders and drivers in Bangladesh, and quantitative data were collected from 300 respondents consisting of riders and drivers using a convenience sampling technique. Factor analysis and hierarchical cluster analysis were applied to the data analysis. The qualitative analysis reveals several significant factors associated with RSS and RHS, including cost efficiency, fare, fuel consumption, traffic congestion, carbon emissions, environmental pollution, employment opportunities, business growth, and security. The quantitative results indicate that using RSS is associated with more significant benefits than RHS in various aspects, including cost efficiency, fare, fuel consumption, traffic congestion, carbon emissions, environmental pollution, employment opportunities, and expansion of the automobile industry. The findings may assist policymakers in understanding how RSS can yield more incredible economic, environmental, and social benefits than RHS by analyzing fare sharing among passengers, carbon emissions, fuel consumption, and the expansion of the vehicle markets etc. Therefore, the government can formulate distinct policies for RSS holders due to their contributions to economic, social, and environmental concerns. While RHS services are available in many cities in Bangladesh, this study considered only Dhaka and Sylhet cities. Thus, future studies can consider more respondents from other cities for a holistic understanding.

Heat stress amplified by climate change causes excessive reductions in labor capacity, work injuries, and socio-economic losses. Yet studies of corresponding impact assessments and adaptation developments are insufficient and incapable of effectively dealing with uncertain information. This gap is caused by the inability to resolve complex channels involving climate change, labor relations, and labor productivity. In this paper, an optimization-based productivity restoration modeling framework is developed to bridge the gap and support decision-makers in making informed adaptation plans. The framework integrates a multiple-climate-model ensemble, an empirical relationship between heat stress and labor capacity, and an inexact system costs model to investigate underlying uncertainties associated with climate and management systems. Optimal and reliable decision alternatives can be obtained by communicating uncertain information into the optimization processes and resolving multiple channels. Results show that the increased heat stress will lead to a potential reduction in labor productivity in China. By solving the objective function of the framework, total system costs to restore the reduction are estimated to be up to 248,700 million dollars under a Representative Concentration Pathway of 2.6 (RCP2.6) and 697,073 million dollars under RCP8.5 for standard employment, while less costs found for non-standard employment. However, non-standard employment tends to restore productivity reduction with the minimum system cost by implementing active measures rather than passive measures due to the low labor costs resulting from ambiguities among employment statuses. The situation could result in more heat-related work injuries because employers in non-standard employment can avoid the obligation of providing a safe working environment. Urgent actions are needed to uphold labor productivity with climate change, especially to ensure that employers from non-standard employment fulfill their statutory obligations.