The H3N2 influenza virus is spiking dramatically, which is a major concern worldwide and in India. The multifunctional hetero-trimer influenza virus RNA-dependent RNA polymerase (RdRP) is involved in the generation of viral mRNA and is crucial for viral infectivity, which is directly related to the virus’s ability to survive. The goal of the current work was to use molecular docking to determine how the RdRP protein might be affected by powerful bioactive chemicals found in Calotropis gigantia latex. By applying CB-dock 2 analysis and 2D interactions, an in-silico docking study was conducted using a GC-FID (gas chromatography with flame-ionization detection) based composition profile. Tocospiro A (15%), Amyrin (7%), and Gombasterol A were found by GC-FID to be the main phytocompounds in the latex of Calotropis gigantia. The docking result showed that ligands were effectively bound to RdRP. According to interaction studies, RdRP/ligand complexes create hydrogen bonds, van der Waals forces, pi-alkyl bonds, alkyl bonds, and pi-Sigma bonds. Therefore, it was suggested that Calotropis gigantia latex may represent a possible herbal remedy to attenuate H3N2 infections based on the above findings of the fragrance profile and docking.

The development of entrepreneurship in fisheries operations is an important component of eliminating poverty. Fisherman obviously produce fishery goods, despite the broad recognition of the positive role that entrepreneurship can play in the reduction of poverty. Integration into one’s society and economy are increasingly beginning to be seen as an essential component of entrepreneurial success. This study aims to investigate the cultural and entrepreneurial attitudes of fishermen involved in the production of fishery products in the Province of West Sumatra, Indonesia, accordingly with a particular focus on marine resource conservation areas in village development. In this development, the descriptive design of capitals was utilized. This design included interviews, a questionnaire survey, and a review of the relevant body of literature. As a result, the purpose of the study was to propose an alternative model for the development of villages that would be considered novel in Indonesia. The findings demonstrated that the model makes a contribution to enhancing the socio-economic, cultural, and social capabilities of a group of fishermen. In conclusion, tourism that is focused on social entrepreneurship has the potential to boost entrepreneurial attitudes as well as the atmosphere surrounding community understanding of creative village development. We came to the conclusion that implementing tourism with a focus on social entrepreneurship could increase entrepreneurial attitudes and create an atmosphere that is more conscious of the needs of the community in village development.

Bael or Aegle marmelos Corrêa is considered a sacred tree by Hindus and is offered to Lord Shiva while worshipping. It grows in the Indian subcontinent and Southeast Asia and is called by various names in different regions. Bael has been used as a traditional medicine in India and other Southeast Asian countries to treat various ailments, including diarrhea, chronic dysentery, constipation, gonorrhea, catarrh, diabetes, deafness, inflammations, ulcerated intestinal mucosa, intermittent fever, melancholia, heart palpitation, and also to control fertility. The ethnomedicinal properties of Bael are owing to its ability to synthesize alkaloids, cardiac glycosides, anthocyanins, flavonoids, steroids, saponins, terpenoids, tannins, lignins, quinones, coumarins, proteins, carbohydrates, amino acids, reducing sugars, fats, and oils. The aegeline, auroptene, umbelliferone, psoralene, marmin, imperatorin, xylorhamnoarabinogalactan I pectic polysaccharide and skimmianine are synthesized by different parts of Bael, and they have shown antibacterial, anti-inflammatory, analgesic, anti-allergic, anthelmintic, antidiabetic, anticancer, cardioprotective and neuroprotective activities in various experimental models. The present review has been written consulting various publications, and different websites including Google Scholar, Pubmed, ScienceDirect, and Google.

The work is devoted to the numerical solution of the initial boundary value problem for the heat equation with a fractional Riesz derivative. Explicit and implicit difference schemes are constructed that approximate the boundary value problem for the heat equation with a fractional Riesz derivative with respect to the coordinate. In the case of an explicit difference scheme, a condition is obtained for the time step at which the difference scheme converges. For an implicit difference scheme, a theorem on unconditional convergence is proved. An example of a numerical calculation using an implicit difference scheme is given. It has been established that when passing to a fractional derivative, the process of heat propagation slows down.

Low integrity is a challenge for any organization. However, most organizations emphasize integrity without explaining what is required of an individual with high integrity. Exhibiting high integrity is necessary for academics; yet, the level of academic integrity remains unclear. Therefore, the purpose of this study is to examine the integrity level of academicians in a Malaysian public university. This paper shares the findings on the level of integrity of academics based on a questionnaire completed by 213 academicians. Data were collected by survey questionnaire and was analyzed using descriptive and inferential statistics. An overall mean score of 9.45 from a possible 10.0 indicated a high level of integrity among academics. The self-evaluation results by academics also demonstrated that they have attained integrity at a high level for their generic task, teaching and learning, research and publications and service for community with a mean score between 9.36 and 9.49. The value with the highest mean score was for “service to community”, whereas the lowest was for “research and publication”. These findings show that the university has successfully instilled values of integrity among academicians. Nevertheless, the university must continue to enhance academic integrity by exploring religiosity. Using Google Scholar, a literature search identified an Islam-based academic integrity model to explain the quantitative findings. Finally, a mixed method approach and involving all universities in Malaysia are recommended to further the findings of this study.

Three-dimensional (3D) bioprinting is a promising technological approach for various applications in the biomedical field. Natural polymers, which comprise the majority of 3D printable “bioinks”, have played a crucial role in various 3D bioprinting technologies during the layered 3D manufacturing processes in the last decade. However, the polymers must be customized for printing and effector function needs in cancer, dental care, oral medicine and biosensors, cardiovascular disease, and muscle restoration. This review provides an overview of 3D bio-printed natural polymers—commonly employed in various medical fields—and their recent development.