Over the last few decades, demographic growth combined with poorly controlled urbanization has confronted African cities with a variety of environmental protection challenges. As part of a gradual awareness-raising process, African countries have ratified conventions and adopted a series of laws to protect the environment. Since independence (1960), Gabon has adopted legal instruments to provide a better framework for environmental protection. Despite the existence of well-developed legislation, the Libreville conurbation faces difficulties in waste management. This situation contributes to the degradation of the coastal zone. This study aims to analyse stakeholders’ perceptions of environmental protection regulations in solid waste management practices along the coastline of the Libreville metropolitan area in Gabon. The methodology includes documentary research, field observations, and surveys of 300 study area participants. The results show that the degradation of the coastline is due to a lack of awareness and compliance with the laws governing environmental protection and waste management. As a result, waste disposal practices such as dumping in nature, waterways, illegal dumps, and gutters are commonplace among the population. To achieve sustainable coastal zone management, it is essential to apply regulatory texts and involve stakeholders in improving planning and the quality of the coastal environment.

Access to affordable and quality medicines plays a vital role for achieving Universal Health Coverage and in reducing out-of-pocket expenditures (OOPE) for households especially in developing nations such as India. Pradhan Mantri Bhartiya Janaushadhi Pariyojana (PMBJP), a Government of India initiative, aims to make low-cost and quality generic drugs and surgical equipment accessible to all segments of the population through its dedicated store outlets known as Pradhan Mantri Bhartiya Janaushadhi Kendra (PMBJK). In this study, a pilot survey comprising 20 stores/PMBJKs and 150 citizens was undertaken in the Bengaluru Urban District, India to understand various aspects of the PMBJKs including availability of drugs, stock-outs, accessibility to stores, perception and awareness levels along with challenges faced by store owners and citizens/beneficiaries. Based on the survey results, we capture the availability of drugs for 35 medicines and consumables belonging to 12 therapeutic categories across 20 store outlets. We also provide valuable insights and interdisciplinary recommendations on several facets including adopting technology-based measures for day-to-day functioning of stores, need for in-depth supply chain analysis for ensuring availability of drugs, encouraging prescription of generic medicines, increasing awareness levels in addition to promoting grassroot-level research, surveys and feedback mechanisms. These suggestions are expected to find their utility in policy-making, strengthen the implementation of the PMBJP scheme across Bengaluru and India as well as contribute towards achieving related Sustainable Development Goals.

Over 90% of cancer-related mortality worldwide is due to metastatic disease since the dynamic tumor microenvironment poses huge challenges in preventing the spread of metastatic cancer. Introducing the advent of advance biomaterials and their swift evolution, this review highlights the great potential of innovative biomaterials to proficiently tackle the metastatic tumor environment. Focusing on four distinct categories of biomaterials systems, action mechanism of biomaterials utilized in anti-tumor therapy is explained in detail: 1. Nanoplatforms sensitive to biochemical cues including pH, redox, and enzymes are known as stimuli-responsive nanoplatforms that react according their environment, 2. Smart nanoplatforms changing their morphology to penetrate impermeable physical barriers at tumor site, 3. Ingenious biomaterial participating in tumor normalization, and 4. Nanoplatforms with real-time theranostic capabilities due to innate feedback-loop mechanism. Ingeniously structured biomaterials with extensive evidence in preclinical efficacy encourage their inclusion in metastatic tumor therapy however, their utilization in medical settings is prevented due to various challenges; impractical manufacturing cost, regulatory and safety issues as well as large-scale production are major challenges restraining their widespread use. A concrete framework is proposed in this review to accelerate the biomaterial structure standardization process, following the GMP and other regulatory guidelines with the aim of implementing biomaterial-based tumor diagnostics and therapies. Since incorporating advancing technologies in tumor therapy such AI-driven, autonomous biomaterial structure or patient-specific tumor models would enable confront the proliferating metastatic tumor cases.

The recession cone and recession function are very important research objects in Convex Analysis. They have extensive applications in the optimization theory. Firstly, we study the properties of the recession cone and recession function. The positive homogeneity and subadditivity of recession function are mainly discussed. And the different methods are considered to prove these properties. Secondly, we discuss the unboundedness of the convex sets and convex functions by using recession cone and recession function.

This paper reconceives zero not as a mere absence but as an axis unifying positive and negative infinities. We introduce the notion of Unzero (Ø) to emphasize zero’s active role in mathematical structure. By analyzing limits of the form n/m as m→0⁺ and m→0⁻, we show that Unzero naturally serves as a pivot between divergent magnitudes. We formalize Unzero within a minimal algebraic extension of the real numbers, compare it with projective and non standard frameworks, and explore illustrative examples in analysis and geometry. This unified perspective clarifies longstanding ambiguities around division by zero, offers a coherent notation respecting classical limits, and suggests avenues for further algebraic and topological development.