Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

The design of effective flood risk mitigation strategies and their subsequent implementation is crucial for sustainable development in mountain areas. The assessment of the dynamic evolution of flood risk is the pillar of any subsequent planning process that is targeted at a reduction of the expected adverse consequences of the hazard impact. This study focuses on riverbed cities, aiming to analyze flood occurrences and their influencing factors. Through an extensive literature review, five key criteria commonly associated with flood events were identified: slope height, distance from rivers, topographic index, and runoff height. Utilizing the network analysis process within Super Decision software, these factors were weighted, and a final flood risk map was generated using the simple weighted sum method. 75% of the data was used for training, and 25% of it was used for testing. Additionally, vegetation changes were assessed using Landsat imagery from 2000 and 2022 and the normalized difference vegetation index (NDVI). The focus of this research is Qirokarzin city as a case study of riverbed cities, situated in Fars province, with Qir city serving as its central hub. Key rivers in Qirokarzin city include the Qara Aghaj River, traversing the plain from north to south; the primary Mubarak Abad River, originating from the east; and the Dutulghaz River, which enters the eastern part of the plain from the southwest of Qir, contributing to plain nourishment during flood events. The innovation of this paper is that along with the objective to produce a reliable delineation of hazard zones, a functional distinction between the loading and the response system (LS and RS, respectively) is made. Results indicate the topographic index as the most influential criterion, delineating Qirokarzin city into five flood risk zones: very low, low, moderate, high, and very high. Notably, a substantial portion of Qirokarzin city (1849.8 square kilometers, 8.54% of the area) falls within high- to very-high flood risk zones. Weighting analysis reveals that the topographic humidity index and runoff height are the most influential criteria, with weights of 0.27 and 0.229, respectively. Conversely, the height criterion carries the least weight at 0.122. Notably, 46.7% of the study area exhibits high flood intensity, potentially attributed to variations in elevation and runoff height. Flood potential findings show that the middle class covers 32.3%, indicating moderate flood risk due to changes in elevation and runoff height. The low-level risk is observed sporadically from the east to the west of the study area, comprising 12.4%. Analysis of vegetation changes revealed a significant decline in forest and pasture cover despite agricultural and horticultural development, exacerbating flood susceptibility. 

Improving educational outcomes in subjects such as English and mathematics remains a significant challenge for educators and policymakers. Strategic Human Resource Management (SHRM), which aligns human resource practices with organizational goals, has proven effective in business sectors but is less explored in educational contexts, especially from students’ perspectives. Existing studies often focus on teacher development, overlooking direct impacts on student performance. This research addresses the gap by examining how SHRM influences students’ performance in English and mathematics, incorporating student feedback to assess SHRM’s effectiveness. In the quantitative study, 200 students were analyzed to explore the relationship between SHRM practices and academic outcomes. The findings indicate that SHRM significantly affects student performance, with high predictive relevance and explanatory power in both subjects. The results suggest that strategic HR practices, such as professional development, performance management, and resource allocation, are critical to academic success. These insights provide valuable implications for educators and policymakers, highlighting the importance of integrating strategic HR management into educational frameworks to enhance curriculum design and resource distribution. The study demonstrates the broad applicability of SHRM across different academic disciplines, suggesting a need for comprehensive HR strategies that focus on both teacher and student performance. Future research should explore how SHRM influences educational outcomes and identify contextual factors that moderate its impact, enhancing effective HR practices in diverse academic settings.

This article is a study of the institutional governance of farmers in Bukit Batu District, Bengkalis Regency using the concept of Society 5.0 and the governance paradigm for analysis in peat area studies. This study aims to determine the form of institutional governance of smallholder agriculture in peat areas and determine the truth of the influence of community economic management and development indicators on Society 5.0, which results from empirical studies in the field. This study uses the mixed methods method, which combines quantitative and qualitative data analysis to measure the truth of information. The results of the study illustrate that the question study first finds existing forms of institutional governance walk, however still passive; this is caused by constraints of knowledge management plant horticulture in the region peat, utilization process nutrients, and management techniques group sustainable farming in aspect regulation government and empowerment company around through CSR; on the question, it has been furthermore found that management variables and community economic development have a positive influence on Society 5.0. This study uses quantitative analysis and calculation results from the SPSS analysis test to support this conclusion. From this study, it formulated recommendation from the synergy between economic development and management of peat areas to socio-economic and environmental impacts that must be considered by interested stakeholders, as well as maximizing function technology in making it easy to manage horticulture plants in peat areas as a form of Society 5.0 to minimize behind.

With the development and progress of the era, digital construction has become an important topic for enterprise development in the new era. Practice has shown that by actively carrying out corresponding digital construction work, enterprises can more comprehensively and systematically analyze the industry development and market prospects, which helps to promote the reasonable adjustment
of internal and external management work modes and the improvement of management efficiency, and has a positive guiding role for the healthy development cycle of enterprises. In this article, the author combines a large amount of research cases to conduct research on the effect of digital construction on enterprise development in the new era and proposes corresponding optimization measures, hoping to further promote the full play of information technology value, in order to safeguard the development of enterprises.