Subcutaneous (SC) drug delivery is one of the best routes of drug administration to patients over intravenous (IV) administration due to the ease of application and patient acceptance. The main limitation of using the SC route is administering larger volumes of drug, greater than 3–5 mL for therapeutic dosages. Wearable injectors on body devices are an attractive option for larger-volume drug delivery to patients. Thus, the need for a self-administration strategy at home is growing faster and is required for the next level of time-dependent and high-volume drug delivery. The advances in low-cost, connected on-body delivery systems hold great opportunity for novel ways of delivering home-based drug therapy in the future.

Climate change has affected the coasts of the world due to numerous factors, including the change in the intensity and frequencies of the storms and the increase in the mean sea level, among others. Argentina has extensive coastal areas, and research and monitoring tasks are expensive and require a significant number of personnel to cover large geographical areas. Given this, citizen science has become a tool to increase scientific research's spatial and temporal extension. Therefore, the paper aims to analyze the methodology and development of the citizen science project in Villa Gesell and its lessons for applying them in future coastal environmental monitoring projects. The methodology was based on an experience of the project co-created between activists and researchers. This project included four phases for social and physical aspects: training for the citizens, theoretic and practical aspects of coastal dynamics, and how to measure its geomorphological and oceanographic variations; data collection: the activists who received the training performed the measurements to monitor the beach; data analysis by scientists; and dissemination of results; the report data were disseminated by citizens in their community. The analysis of case studies in citizen science projects generates a fundamental learning arena to apply in future projects. Among the positive aspects were the phases established for their development and the methodology used to collect beach monitoring data.

Recently, Agile project management has received significant academic and industry attention from due to its advantages, such as decreased costs and time, increased effectiveness, and adaptiveness towards challenging business environments. This study primarily aims to investigate the relationship between the success factors and Agile project management methodology adoption and examine the moderating effect of perceived compatibility. The technology-organization-environment (TOE) framework and technology acceptance theories (UTAUT, IDT, and TAM) were applied as the theoretical foundation of the current study. A survey questionnaire method was employed to achieve the study objectives, while quantitative primary data were gathered using a carefully designed methodological approach focusing on Omani oil and gas industry. The PLS-SEM technique and SmartPLS software were used for hypotheses testing and data analysis. Resultantly, readiness, technology utilization, organizational factors, and perceived compatibility were the significant factors that promoted Agile methodology adoption in the oil and gas industry. Perceived compatibility moderated the relationship between success factors and Agile methodology. The findings suggested that people, technology, and organizational factors facilitate the Agile methodology under the technology acceptance theories and frameworks. Relevant stakeholders should adopt the study outcomes to improve Agile methodology adoption.

China's famous educator Mr. Tao Xingzhi once said that "education is the first, observation first", only scientific and effective observation can change the teachers' narrow understanding of kindergarten curriculum. From the observation record to the derived "Little Secrets in the Toilet" garden-based course, the original is just an ordinary life segment, become warm, have curriculum awareness. With an observational perspective, the teachers capture the interests and needs of the children in their lives, understand their experience levels, and provide valuable learning growth points. At the same time, in the activity, teachers reflect on their own educational content, organization mode and environment creation, and make dynamic adjustment and transformation, which promotes the development of children and improves teachers' leadership in the curriculum.

Different color-promoting treatments were tested on table grape cv. “Flame Seedlees” to evaluate changes on flavonoids such as anthocyanins and the residual ethylene produced. Treatments were spray-applied at the onset of veraison. The control was Ethrel at 250 ppm (ETH), Salicylic Acid at 100 ppm (AS), Melatonin at 25 ppm (MEL) and 1:1 mixtures of ETH+AS, ETH+MEL and AS+MEL. The trials were conducted in triplicate after harvest, measuring Total Soluble Solids (% TSS), total acidity (% tartaric acid), pH, residual ethylene (ppm) and anthocyanin content (mg∙cm^-2). It was found that treatments ETH, AS, MEL and ETH+AS reached 16% TSS, standing out with lower values ETH +MEL (14.27%) and AS+MEL (15.17%) (p ≤ 0.05). ETH reached 0.83 ppm of residual ethylene, while a sum effect was appreciated in ETH+AS (0.5 ppm) and ETH+MEL (0.35 ppm), but not beneficial as it did not reflect quality characteristics. Only differences (p ≤ 0.05) in anthocyanin content were recorded between ETH (0.019 mg∙cm^-2) and AS+MEL (0.003 mg∙cm^-2). The subjective color of the grape bunches in the field made it possible to relate it to the objective results of the analyses performed. This research provides commercially important information on the substitution of Ethrel by natural compounds such as AS and MEL, as they show similar effects on the quality of “Flame Seedless” table grapes. In addition, these compounds do not have an ethylene residual greater than 0.2 mg/kg.

Arbuscular mycorrhizal fungi (AMF) increase the uptake of soluble phosphates, while phosphorus solubilizing fungi (S) promote the solubilization of insoluble phosphate complexes, together benefiting plant nutrition. The use of these organisms in combination with minerals or rocks that provide nutrients is another alternative to maintain crop productivity. The objective of this work was to combine AMF and S with pyroclastic materials (ashes and pumicites) from the Puyehue volcano and phosphoric rocks (PR) from the Río Chico Group (Chubut) and to evaluate the performance of these mixtures as substrates for potted production of Lactuca sativa. To formulate the substrates, a mixture of Ter-rafertil® with ashes was used as a base. Penicillium thomii was the S and spores of the fungus Rhizophagus intraradices (AEGIS® Irriga) served as the source of AMF. Various combinations of microorganisms and the addition or not of RP were evaluated. The treatments were: (1) substrate; (2) substrate + AMF; (3) substrate + S; (4) substrate + AMF + S; (5) substrate: PR; (6) substrate: PR + AMF; (7) substrate: PR + S, and (8) substrate: PR + AMF + S. There were 3 replicates per treatment. The parameters evaluated were total and assimilable P content in the substrate, P in plant tissue and dry biomass. All of them were significantly higher in the plants grown in the substrate added with PR and inoculated with S and AMF. This work confirms that the S/AMF combination with volcanic ashes from Puyehue and PR from Grupo Río Chico formulated with a commercial substrate promote the growth of L. sativa. Thus, it is possible to increase the added value of geomaterials of national origin.