Amyloidosis is a systemic disorder produced by the deposition of insoluble protein fibrils that fold and deposit in the myocardium. Patients with amyloidosis and cardiac involvement have higher mortality than patients without cardiac involvement. The two most prevalent forms of amyloidosis associated with cardiac involvement are AL amyloidosis, due to the deposition of immunoglobulin light chains, and ATTR amyloidosis, due to the deposition of the transthyretin (TTR) protein in mutated or senile form. This article aims to review the different cardiac imaging modalities (echocardiography, cardiac magnetic resonance imaging, nuclear medicine and tomography) that allow to determine the severity of cardiac involvement in patients with amyloidosis, the type of amyloidosis and its prognosis. Finally, we suggest a diagnostic algorithm to determine cardiac involvement in amyloidosis adapted to locally available diagnostic tools, with a practical and clinical approach.
The present paper discusses the case of the Madrid Nuevo Norte Project (MNNP) in order to examine the relation of this mega-project with the city’s sustainable development. For this reason, the study used a qualitative approach using semi-structural interviews with experts (Madrid’s town hall, Madrid State, and the program management office and other external) that relayed strongly with MNNP. The expert panel requirements are split in six expertise areas: sustainability, urban development, urban planning, government or public affairs, project management or Madrid Nuevo Norte (MNN) key stakeholders. The study highlighted the vital importance of MNNP as a flagship sustainable project for the rest of Europe, that meets sustainability criteria for contributing substantially in the improvement of the quality of life of final users and for the community in general. For instance, it contributes to the regeneration of the city’s degraded area, to the interconnection of an isolated part of the city and public transportation connection, improving the external image of Madrid. Despite of it, there are some challenges that should be carefully managed such as applying sustainable solutions from other cities not properly tailored to Madrid, housing pricing accessibility increase due to the lack of terrain in Madrid and the politization of the project as discussion topic between local parties. In this context, local authorities should give particular emphasis in complying with the principles of sustainability for improving the overall performance of MNNP, ensuring social justice and prosperity for the people of Madrid.
Oil spill clean-up is a long-standing challenge for researchers to prevent serious environmental pollution. A new kind of oil-absorbent based on silicon-containing polymers (e.g., poly(dimethylsiloxane) (PDMS)) with high absorption capacity and excellent reusability was prepared and used for oil-water separation. The PDMS-based oil absorbents have highly interconnected pores with swellable skeletons, combining the advantages of porous materials and gels. On the other hand, polymer/silica composites have been extensively studied as high-performance functional coatings since, as an organic/inorganic composite material, they are expected to combine polymer flexibility and ease of processing with mechanical properties. Polymer composites with increased impact resistance and tensile strength without decreasing the flexibility of the polymer matrix can be achieved by incorporating silica nanoparticles, nanosand, or sand particles into the polymeric matrices. Therefore, polymer/silica composites have attracted great interest in many industries. Some potential applications, including high-performance coatings, electronics and optical applications, membranes, sensors, materials for metal uptake, etc., were comprehensively reviewed. In the first part of the review, we will cover the recent progress of oil absorbents based on silicon-containing polymers (PDMS). In the later details of the review, we will discuss the recent developments of functional materials based on polymer/silica composites, sand, and nanosand systems.
This study explores the dynamic relationship between ethical human resources management (HRM) strategies, the level of commitment an employee feels towards their organization, and their job performance, paying particular attention to how employees’ perceptions of the support they receive from their organization can influence these interactions, especially during challenging times. Drawing on a sample of full-time non-executive Indonesian employees, the research employs descriptive statistics for initial data analysis, followed by structural equation modeling (SEM) to test the proposed hypotheses rigorously. The investigation reveals a positive relationship between ethical HRM and employee performance (EP) and organizational commitment (OC). Additionally, OC emerges as a pivotal mediator in the ethical HRM-EP link. Notably, employees’ organizational support perception (EOSP), often assumed to enhance positive organizational outcomes, displays a surprising negative moderating effect when combined with OC, suggesting a more intricate relationship than traditionally posited. These findings enhance our comprehension of how ethical HRM practices function in times of crisis, questioning conventional beliefs regarding the influence of organizational support. The study’s methodological approach, combining descriptive and advanced statistical analyses, provides a robust framework for understanding these complex relationships. This research holds significant implications for HRM practices, particularly in crisis response and management, indicating a need for nuanced support strategies that reflect the complexity of employee-organization dynamics.
For this, the primary aim of this study was to analyze of the impact of cultural accessibility and ICT (information and communication technology) infrastructure on economic growth in Kazakhstan, employing regression models to asses a single country data from 2008 to 2022. The research focuses on two sets of variables: cultural development variables (e.g., number of theaters, museums, and others) and ICT infrastructure variables (e.g., number of fixed Internet subscribers, total costs of ICT, and others). Principal component analysis (PCA) as employed to reduce the dimensionality of the data and identify the most significant predictors for the regression models. The findings indicate that in the cultural development model (Model 1), the number of recreational parks and students are significant positive predictors of GDP per capita. In the ICT infrastructure model (Model 2), ICT costs are found to have a significant positive impact on GDP per capita. Conversely, traditional connectivity indicators, such as the number of fixed telephone lines, show a low dependence on economic growth, suggesting diminishing returns on investment in these outdated forms of ICT. These results suggest that investments in cultural and ICT infrastructure are crucial for economic development. The study provides valuable insights for policymakers, emphasizing the need for quality improvements in education and strategic modernization of communication technologies.
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