This paper presents a brief review of risk studies in Geography since the beginning of the 20th century, from approaches focused on physical-natural components or social aspects, to perspectives that incorporate a systemic approach seeking to understand and explain risk issues at a spatial level. The systemic approach considers principles of interaction between multiple variables and a dynamic organization of processes, as part of a new formulation of the scientific vision of the world. From this perspective, the Complex Systems Theory (CST) is presented as the appropriate conceptual-analytical framework for risk studies in Geography. Finally, the analysis and geographic information integration capabilities of Geographic Information Systems (GIS) based on spatial analysis are explained, which position it as a fundamental conceptual and methodological tool in risk analysis from a systemic approach.