In the domains of geological study, natural resource exploitation, geological hazards, sustainable development, and environmental management, lithological mapping holds significant importance. Conventional approaches to lithological mapping sometimes entail considerable effort and difficulties, especially in geographically isolated or inaccessible regions. Incorporating geological surveys and satellite data is a powerful approach that can be effectively employed for lithological mapping. During this process, contemporary RS-enhancing methodologies demonstrate a remarkable proficiency in identifying complex patterns and attributes within the data, hence facilitating the classification of diverse lithological entities. The primary objective of this study is to ascertain the lithological units present in the western section of the Sohag region. This objective will be achieved by integrating Landsat ETM⁺ satellite imagery and field observations. To achieve our objectives, we employed many methodologies, including the true and false color composition (FCC&TCC), the minimal noise fraction (MNF), principal component analysis (PCA), decoration stretch (DS), and independent component analysis (ICA). Our findings from the field investigation and the data presented offer compelling evidence that the distinct lithological units can be effectively distinguished. A recently introduced geology map has been incorporated within the research area. The sequence of formations depicted in this map is as follows: Thebes, Drunka, Katkut, Abu Retag, Issawia, Armant, Qena, Abbassia, and Dandara. Implementing this integrated technique enhances our comprehension of geological units and their impacts on urban development in the area. Based on the new geologic map of the study area, geologists can improve urban development in the regions by detecting building materials “aggregates”. This underscores the significance and potential of our research in the context of urban development.