The study is focusing on cyberspace—a new type of space mastered by humans with the help of digital technologies. This systematic review uses SPAR-4-SLR protocol to analyze over 30 years of scholarly research indexed in Scopus database, highlighting five time periods: before 1995, 1996–2008, 2009–2012, 2013–2019, and after 2020. A final sample of 6645 publications in social sciences, Business, management and accounting (BMA), and Economics, econometrics and finance (EEF) was analyzed across multiple parameters, including: chronology, types of documents, sources, countries, institutions, authors, topics, and most cited publications. The review has systematized information about the most influential organizations and individuals involved in cyberspace research. First of all, these are researchers from the United States, the United Kingdom, and China. Key journals that publish research on the topic have been identified, and a ranked list of funding organizations supporting research on the social and economic aspects of cyberspace are identified. The study provides insights into the achievements of the social and economic sciences in cyberspace over the past 30 years. The results will be useful to scholars who seek for a general overview on the topic of cyberspace, as well as experts and policymakers developing mechanisms and tools for regulating cyberspace as a mixture of the virtual and real worlds.