A comprehensive proteomic analysis was carried out to evaluate leaf proteome changes of Brassica napus cultivars as an important oilseed crop inoculated with the bacterium Pseudomonas fluorescens FY32 under salt stress. Based on the physiochemical characteristics of canola, Hyola308 was a tolerant and Sarigol was a salt sensitive cultivar. Gel-based proteomics indicated that proteins related to energy/metabolism, cell/membrane maintenance, signalins, stress, and development respond to salt stress and bacterial inoculation in both cultivars. Under salt stress, Hyola308 launches mechanisms similar to Sarigol, but the tolerance was related to consuming less energy consumption than Sarigol for launching the proper pathway/mechanism. Inoculation with plant growth promoting bacteria promotes relative growth rate and net assimilation rate; causes increase in soluble sugar content (12–32% varing to cultivars and salt treatments), as an osmo-protectant, in leaves of Sarigol and Hyola308 in control and salt stress conditions. The groups of proteins that are affected due to inoculation (18 and14 functional groups in Hyola308 and Sarigol, respectively) are varying to stress-influenced groups (10 and 6 functional groups in Hyola308 and Sarigol, respectively) that might be because of regulating tolerance mechanism of plant and/or plant-growth promoting bacteria inoculation. Furthermore, it is recognized that P. fluorescens FY32 has a dual effect on the cultivars including a pathogenic effect and a growth promoting effect on both cultivars under salt stress.
Polyurethane is a multipurpose polymer with valuable mechanical, thermal, and chemical stability, and countless other physical features. Polyurethanes can be processed as foam, elastomer, or fibers. This innovative overview is designed to uncover the present state and opportunities in the field of polyurethanes and their nanocomposite sponges. Special emphasis has been given to fundamentals of polyurethanes and foam materials, related nanocomposite categories, and associated properties and applications. According to literature so far, adding carbon nanoparticles such as graphene and carbon nanotube influenced cell structure, overall microstructure, electrical/thermal conductivity, mechanical/heat stability, of the resulting polyurethane nanocomposite foams. Such progressions enabled high tech applications in the fields such as electromagnetic interference shielding, shape memory, and biomedical materials, underscoring the need of integrating these macromolecular sponges on industrial level environmentally friendly designs. Future research must be intended to resolve key challenges related to manufacturing and applicability of polyurethane nanocomposite foams. In particular, material design optimization, invention of low price processing methods, appropriate choice of nanofiller type/contents, understanding and control of interfacial and structure-property interplay must be determined.
Polyurethane is a multipurpose polymer with valuable mechanical, thermal, and chemical stability, and countless other physical features. Polyurethanes can be processed as foam, elastomer, or fibers. This innovative overview is designed to uncover the present state and opportunities in the field of polyurethanes and their nanocomposite sponges. Special emphasis has been given to fundamentals of polyurethanes and foam materials, related nanocomposite categories, and associated properties and applications. According to literature so far, adding carbon nanoparticles such as graphene and carbon nanotube influenced cell structure, overall microstructure, electrical/thermal conductivity, mechanical/heat stability, of the resulting polyurethane nanocomposite foams. Such progressions enabled high tech applications in the fields such as electromagnetic interference shielding, shape memory, and biomedical materials, underscoring the need of integrating these macromolecular sponges on industrial level environmentally friendly designs. Future research must be intended to resolve key challenges related to manufacturing and applicability of polyurethane nanocomposite foams. In particular, material design optimization, invention of low price processing methods, appropriate choice of nanofiller type/contents, understanding and control of interfacial and structure-property interplay must be determined.
The MDA-MB-231 cell line is derived from triple-negative breast cancer (TNBC), representing one of the most aggressive forms of breast cancer. Innovative therapeutic strategies, including s targeted therapies using nanocarriers, hold significant promise, particularly for difficult-to-treat cancers such as TNBC. Nanoparticles have transformed the medical field by serving as advanced drug delivery systems for cancer treatment. They play a critical role in overcoming the drug resistance often associated with cancer therapies. When utilized as drug delivery vehicles, nanoparticles can specifically target cancer cells and effectively reduce or eliminate multidrug resistance. Among them, chitosan-coated magnetic nanoparticles (MNPs) have been widely explored for the loading and controlled release of various anticancer agents. In this study, we evaluated the effects of dexamethasone-loaded chitosan-coated MNPs on MDA-MB-231 cell lines. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to verify the successful loading of dexamethasone onto the nanoparticles. To assess cytotoxicity, empty nanoparticles, free drug, and drug-loaded nanoparticles were tested on the cells. The results indicated that empty nanoparticles exhibited no toxic effects. The IC50 value of the free drug was 123 µg/mL, while the IC50 value of the drug-loaded nanoparticles was significantly lower, at 63 µg/mL. These findings confirmed the successful conjugation of dexamethasone to the chitosan-coated MNPs, demonstrating substantial cytotoxic effects on breast cancer cells. Although dexamethasone has been reported to exhibit both tumor-suppressive and pro-metastatic effects, its specific impact on TNBC warrants further investigation in future studies.
Exposure to high-frequency (HF) electromagnetic fields (EMF) has various effects on living tissues involved in biodiversity. Interactions between fields and exposed tissues are correlated with the characteristics of the exposure, tissue behavior, and field intensity and frequency. These interactions can produce mainly adverse thermal and possibly non-thermal effects. In fact, the most expected type of outcome is a thermal biological effect (BE), where tissues are materially heated by the dissipated electromagnetic energy due to HF-EMF exposure. In case of exposure at a disproportionate intensity and duration, HF-EMF can induce a potentially harmful non-thermal BE on living tissues contained within biodiversity. This paper aims to analyze the thermal BE on biodiversity living tissues and the associated EMF and bio-heat (BH) governing equations.
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