Freeze-thawing plays a vital role in enhancing materials in medicines. Here, we describe the F-T process of synthesis of Poly (vinyl alcol)- Methylene blue single strand- Mxene (PVA–MB-ssDNA –Mxene), which may be effective for gen delivery applications. The PVA –MB-ssDNA –Mxene hydrogel was formed using 1,3,5 consecutive cycles. We also demonstrated that PVA –MB-ssDNA –Mxene hydrogel can be formed by the affection of DNA with PVA and the MXene network. The F-T process shows the new intra molecular bond of PVA-PVA, compared to the non F-T hydrogel which formed by a biologic crosslinking as MB-ssDNA. Scanning electron microscopy reported that the microstructure. The differential scan shows three endothermic peaks at 70, 180, and 300 ℃ for water loss and decomposition. The swelling behavior rapidly increased due to the PVA chains in the F-T methods and then became stable. With a high concentration of MB-DNA, the tensile strength was slightly high, and the swelling behavior was low. Our results indicated that the PVA –MB-ssDNA –Mxene hydrogel using F-T process would have more suitable structural features as gene hydrogel carrier which need greater mechanical strength and stability in body analyses.

In response to the rapid and dynamic changes in the economic environment, companies must improve their processes to maintain competitiveness. This includes enhancing their intellectual capital, with particular emphasis on effective onboarding processes, which play a crucial role in integrating new employees and retaining talent. This enhances the value of the organization’s intellectual capital and emphasizes onboarding—the training and integration of new employees—whose proper functioning impacts staff retention. Drawing on both Hungarian and predominantly foreign literature, we highlight onboarding processes and examine their implementation in Hungarian companies of various sizes. The research employed a mixed-method approach, combining semi-structured interviews and questionnaires. In-depth interviews were conducted with HR leaders from 13 Hungarian organizations to explore the existence of mentoring programs. Additionally, 161 employees across Hungary completed questionnaires, which examined their perspectives on onboarding processes and the relationship between mentoring programs and company size. We analyzed the data using chi-square tests to assess the strength of these relationships. While all large companies in our sample had formal mentoring programs, smaller companies displayed more variability, with some relying on informal or ad-hoc onboarding processes. Based on these results, we identified several key areas for improvement in onboarding processes. These include enhancing the structure of feedback interviews, ensuring more comprehensive communication channels, and strengthening mentoring programs across companies of all sizes. By addressing these gaps, companies can improve employee retention, engagement, and overall integration during the onboarding process, contributing to a more stable and motivated workforce.

The presented article focusses on the analysis of perception of the university social responsibility through the eyes of Slovak university students. The aim is to compare how the values, efficiency of the organisation (university), and the educational process influence the perception of social responsibility among university students themselves. The research is based on the application of quantitative methodology towards the evaluation of differences and similarities in perceptions using two types of tests for statistical analysis, comparative (Mann-Whitney U test) and correlational (bivariate correlation matrix of Spearman’s rho).The results of the research provide a deeper understanding of how universities can shape students’ approach to social responsibility through their values and educational processes, which has important implications for the development of university policies and practices.

The objective of this research was to analyze several reading and writing methods used in educational settings, evaluating their pedagogical approaches and their effectiveness in the process of learning to read and write in school-age children. A systematic review was carried out in the open databases Dialnet and ScieELO, using different inclusion and exclusion criteria, which resulted in 164 documents, applying the PRISMA protocol, 20 were selected. A narrative synthesis analysis was carried out on the following dimensions: reading and writing methods, applied strategies, similarities with other methods and impact on the development of literacy. It is concluded that the combined application of the methods of synthetic and analytical approaches to reading and writing paves the way to attend to the diversity of learning styles, facilitates the strengthening of specific linguistic skills, and strengthens reading comprehension and writing competence.

Despite having a strategic position in supporting the Indonesian economy, the productivity of SME’s is still suboptimal. The increase in the number of SME’s has not been followed by increased competitiveness due to various limitations experienced by this sector. In an effort to provide a comprehensive picture in improving the performance of food processing SME’s in developing countries such as Indonesia, the purpose of this study was to examine the function of product innovation, internet marketing, and brand identity in shaping competitive advantage having an impact on business performance. This research is focused on food processing SME’s in the city of Bogor. The number of samples used was 100 SME’s. The sampling method used the non-probability sampling method with a snowball sampling technique. The data obtained were analyzed using the Structural Equation Model (SEM). Based on the age characteristic of business actors, the majority of business actors were 40–50 years old, of which 52% had their final formal education at high school level. As many as 61% of respondents had attended business training. Based on the results of the Partially Least Square (PLS) SEM analysis, it was found that product innovation, internet marketing and brand identity all had a significant positive effect on competitive advantage and business performance. The influence of brand identity on competitive advantage had the greatest effect, with a value of 0.451. This study contributes to existing research by examining the determinants of the business performance of processed food SME’s through the holistic model offered. This research is innovative because the business raises new issues related to internet marketing by SME’s and investigates them empirically.

The existence of residential well-being of the locals in the sense of equilibrium-state is a competitive advantage for tourism in a given destination. The rise of overtourism could jeopardize this equilibrium and ultimately the effectiveness of tourism in a vulnerable destination. The research question of the study aimed to answer: what are the spiral dynamics of the multifactorial characteristics of the sense of place that can be mapped under the influence of overtourism. Answering the question draws attention to the sense of place—which can be interpreted as a synonym for local character—of the issues of overtourism and residential well-being. Mapping the mechanism of action of the multifactorial characteristic of locality can help to identify non-supportive functions, to pinpoint the balance point for moving towards a supportive quality, and to answer the “how yes” questions at individual, local and collective levels. The answer to the research question is the result of concluding three district-specific sub-questions. The assessment of the results was based on the content analysis of 251 posts (2017–2021) in the local public Facebook group (supplemented by a questionnaire survey of local residents (2022), 30 in-depth interviews with experts and residents (2022) conducted as part of the cross-sectional research, and 10 additional in-depth interviews with residents (2024) conducted for the last sub-question. The flowchart showing the current state of the district along a negative spiral dynamic, the possibility to turn it in a positive direction, and the mind-map-like summary of local, individual and collective mitigation and solution alternatives supporting the change of direction can be considered as a novel scientific result.