Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. Cisplatin-loaded nanoparticle formulations were optimized utilizing response surface methods and the central composite rotating design model. This study employed a central composite rotatable design with a three-factored factorial design with three tiers. Three independent variables namely drug polymer ratio, aqueous organic phase ration, and stabilizer concentration were used to examine the particle size, entrapment efficiency, and drug loading of cisplatin PLGA nanoparticles as responses. The results revealed that this response surface approach might be able to be used to find the best formulation for the cisplatin PLGA nanoparticles. A polymer ratio of 1:8.27, organic phase ratio of 1:6, and stabilizer concentration of 0.15 were found to be optimum for cisplatin PLGA nanoparticles. Nanoparticles made under the optimal conditions found yielded a 112 nm particle size and a 95.4 percent entrapment efficiency, as well as a drug loading of 9 percent. The cisplatin PLGA nanoparticles tailored for scanning electon microscopy displayed a spherical form. A series of in vitro tests showed that the nanoparticle delivered cisplatin progressively over time. According to this work, the Response Surface Methodology (RSM) employing the central composite rotatable design may be successfully used to simulate cisplatin-PLGA nanoparticles.

The purpose of this work is to present the model of a Parabolic Trough Solar Collector (PTC) using the Finite Element Method to predict the thermal behavior of the working fluid along the collector receiver tube. The thermal efficiency is estimated based on the governing equations involved in the heat transfer processes. To validate the model results, a thermal simulation of the fluid was performed using Solidworks software. The maximum error obtained from the comparison of the modeling with the simulation was 7.6% at a flow rate of 1 L/min. According to the results obtained from the statistical errors, the method can effectively predict the fluid temperature at high flow rates. The developed model can be useful as a design tool, in the optimization of the time spent in the simulations generated by the software and in the minimization of the manufacturing costs related to Parabolic Trough Solar Collectors.

The northern territories of Russia need high-quality strategic digital changes in the structure of the regional economy. Digitalization and the introduction of digital technologies in the medium term will be able to transform economic relations in the old industrial and raw materials regions of the North, improve the quality of life of local communities. The growth of digital inequality among the regions under study leads to disproportions in their socio-economic development. The purpose of this study is to develop and test a methodology for assessing the level of development of the digital infrastructure of the Russian northern regions, including classification of an indicators system for each level of digital infrastructure, calculation of an integral index and typology of the territories under study. The objects of the study were 13 northern regions of the Russian Federation, the entire territory of which is classified as regions of the Extreme North and equivalent areas. The methodology made it possible to determine the level of technical, technological and personnel readiness of the northern regions for digitalization, to identify regions with the best solutions at each level of digital infrastructure development. The analysis of the results in dynamics helped to assess the effectiveness of regional policy for managing digitalization processes. As a result, the authors came to the conclusion that increasing the competitiveness of northern regions in the era of rapid digitalization is possible through investments in human capital and the creation of a network of scientific and technological clusters. The presented approach to assessing the development of individual levels and elements of digital infrastructure will allow for the diagnosis of priority needs of territories under study in the field of digitalization. The results of the study can form the basis for regional policy in the field of sustainable digital development of Russia.

The design of effective flood risk mitigation strategies and their subsequent implementation is crucial for sustainable development in mountain areas. The assessment of the dynamic evolution of flood risk is the pillar of any subsequent planning process that is targeted at a reduction of the expected adverse consequences of the hazard impact. This study focuses on riverbed cities, aiming to analyze flood occurrences and their influencing factors. Through an extensive literature review, five key criteria commonly associated with flood events were identified: slope height, distance from rivers, topographic index, and runoff height. Utilizing the network analysis process within Super Decision software, these factors were weighted, and a final flood risk map was generated using the simple weighted sum method. 75% of the data was used for training, and 25% of it was used for testing. Additionally, vegetation changes were assessed using Landsat imagery from 2000 and 2022 and the normalized difference vegetation index (NDVI). The focus of this research is Qirokarzin city as a case study of riverbed cities, situated in Fars province, with Qir city serving as its central hub. Key rivers in Qirokarzin city include the Qara Aghaj River, traversing the plain from north to south; the primary Mubarak Abad River, originating from the east; and the Dutulghaz River, which enters the eastern part of the plain from the southwest of Qir, contributing to plain nourishment during flood events. The innovation of this paper is that along with the objective to produce a reliable delineation of hazard zones, a functional distinction between the loading and the response system (LS and RS, respectively) is made. Results indicate the topographic index as the most influential criterion, delineating Qirokarzin city into five flood risk zones: very low, low, moderate, high, and very high. Notably, a substantial portion of Qirokarzin city (1849.8 square kilometers, 8.54% of the area) falls within high- to very-high flood risk zones. Weighting analysis reveals that the topographic humidity index and runoff height are the most influential criteria, with weights of 0.27 and 0.229, respectively. Conversely, the height criterion carries the least weight at 0.122. Notably, 46.7% of the study area exhibits high flood intensity, potentially attributed to variations in elevation and runoff height. Flood potential findings show that the middle class covers 32.3%, indicating moderate flood risk due to changes in elevation and runoff height. The low-level risk is observed sporadically from the east to the west of the study area, comprising 12.4%. Analysis of vegetation changes revealed a significant decline in forest and pasture cover despite agricultural and horticultural development, exacerbating flood susceptibility. 

This research investigates the impact of modern technological methods of knowledge management (KM) and total quality management (TQM) on the performance of faculty members in educational colleges in Jordan. Drawing on a survey conducted with 306 faculty members, the study examines the influence of technology on teaching methodologies and academic quality within the Jordanian higher education context. The study utilizes the Technology Acceptance Model (TAM) to back up the modern technological methods of knowledge management (KM) and total quality management (TQM) models. The findings reveal a generally positive perception among respondents regarding the beneficial effects of modern technological tools on teaching effectiveness, collaboration, and innovation. Additionally, technology-enhanced TQM practices were found to contribute to improvements in curriculum design, student engagement, and administrative processes. Regression and correlation analyses support significant relationships between technology-enabled KM and TQM practices and faculty performance, highlighting the transformative role of technology in shaping the future of higher education in Jordan. Recommendations are provided for educational institutions to enhance the integration of technology and foster a culture of innovation and continuous improvement among faculty members.

Small watershed ecological compensation is an important economic means to solve the contradiction between protecting the ecological environment and developing the economy. Taking the Changtian small watershed in the Xixiu District of Anshun City as an example, this paper uses the ecological service function value method to roughly calculate the ecological service function value of the small watershed ecosystem: the ecological service function value of the Changtian small watershed is 913.586 million yuan, and the total amount of ecological compensation is 11.6245 million yuan, of which the farmland system compensation is 1.3194 million yuan, the forest system compensation is 7.5336 million yuan, and the water system compensation is 256,000 yuan, The compensation for the fruit forest system is 2,515,500 yuan. Based on the value of ecosystem service function, the compensated and non-compensated ecosystem service functions are distinguished, and the equivalent factors that different ecosystems can provide compensated ecosystem functions are expressed, so that the determination of ecological compensation amount is scientific and more accurate, and then provides a basis for the determination of ecological compensation standard of the small watershed.