Over 90% of cancer-related mortality worldwide is due to metastatic disease since the dynamic tumor microenvironment poses huge challenges in preventing the spread of metastatic cancer. Introducing the advent of advance biomaterials and their swift evolution, this review highlights the great potential of innovative biomaterials to proficiently tackle the metastatic tumor environment. Focusing on four distinct categories of biomaterials systems, action mechanism of biomaterials utilized in anti-tumor therapy is explained in detail: 1. Nanoplatforms sensitive to biochemical cues including pH, redox, and enzymes are known as stimuli-responsive nanoplatforms that react according their environment, 2. Smart nanoplatforms changing their morphology to penetrate impermeable physical barriers at tumor site, 3. Ingenious biomaterial participating in tumor normalization, and 4. Nanoplatforms with real-time theranostic capabilities due to innate feedback-loop mechanism. Ingeniously structured biomaterials with extensive evidence in preclinical efficacy encourage their inclusion in metastatic tumor therapy however, their utilization in medical settings is prevented due to various challenges; impractical manufacturing cost, regulatory and safety issues as well as large-scale production are major challenges restraining their widespread use. A concrete framework is proposed in this review to accelerate the biomaterial structure standardization process, following the GMP and other regulatory guidelines with the aim of implementing biomaterial-based tumor diagnostics and therapies. Since incorporating advancing technologies in tumor therapy such AI-driven, autonomous biomaterial structure or patient-specific tumor models would enable confront the proliferating metastatic tumor cases.

The persistence of coastal ecosystems is jeopardized by deforestation, conversion, and climate change, despite their capacity to store more carbon than terrestrial vegetation. The study’s objectives were to investigate how spatiotemporal changes impacted blue carbon storage and sequestration in the Satkhira coastal region of Bangladesh over the past three decades and, additionally to assess the monetary consequences of changing blue carbon sequestration. For analyzing the landscape change (LSC) patterns of the last three decades, considering 1992, 2007, and 2022, the LSC transformations were evaluated in the research area. Landsat 5 of 1992 and 2007, and Landsat 8 OLI-TIRS multitemporal satellite images of 2022 were acquired and the Geographical Information System (GIS), Remote Sensing (RS) techniques were applied for spatiotemporal analysis, interpreting and mapping the output. The spatiotemporal dynamics of carbon storage and sequestration of 1992, 2007, and 2022 were evaluated by the InVEST carbon model based on the present research years. The significant finding demonstrated that anthropogenic activity diminished vegetation cover, vegetation land decreased by 7.73% over the last three decades, and agriculture land converted to mariculture. 21.74% of mariculture land increased over the last 30 years, and agriculture land decreased by 12.71%. From 1992 to 2022, this constant LSC transformation significantly changed carbon storage, which went from 11,706.12 Mega gram (Mg) to 9168.03 Mg. In the past 30 years, 2538.09 Mg of carbon has been emitted into the atmosphere, with a combined market worth of almost 0.86 million USD. The findings may guide policymakers in establishing a coastal management strategy that will be beneficial for carbon storage and sequestration to balance socioeconomic growth and preserve numerous environmental services.

Small and medium-sized enterprises (SMEs) play a critical role in achieving environmental sustainability, particularly in developing economies where regulatory enforcement and resource constraints remain significant challenges. Drawing on Institutional Theory, this study examines how green leadership influences environmental performance in Ghanaian SMEs, with digital innovation as a mediating variable and environmental culture as a moderating variable. Institutional Theory provides the conceptual foundation for explaining how normative pressures embedded in leadership values and organizational culture, alongside mimetic pressures associated with digital innovation adoption, shape firms’ environmental outcomes. Using survey data collected from SMEs in Ghana and analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM), the results revealed that green leadership has a significant positive effect on both digital innovation and environmental performance. Digital innovation also significantly enhances environmental performance and partially mediates the relationship between green leadership and environmental performance. Notably, the findings demonstrated that environmental culture significantly moderates the relationship between digital innovation and environmental performance, with the effect stronger in organizations with a well-developed environmental culture. This indicates that internalized environmental values amplify the effectiveness of digital innovation initiatives. The study contributes to the sustainability and organizational literature by extending Institutional Theory to the SME context in a developing economy and by clarifying the conditional role of environmental culture in translating digital innovation into superior environmental performance. Practically, the findings suggest that SME leaders and policymakers should promote environmentally oriented leadership, invest in digital innovation, and cultivate strong environmental cultures to enhance sustainability outcomes.