Accurate drug-drug interaction (DDI) prediction is essential to prevent adverse effects, especially with the increased use of multiple medications during the COVID-19 pandemic. Traditional machine learning methods often miss the complex relationships necessary for effective DDI prediction. This study introduces a deep learning-based classification framework to assess adverse effects from interactions between Fluvoxamine and Curcumin. Our model integrates a wide range of drug-related data (e.g., molecular structures, targets, side effects) and synthesizes them into high-level features through a specialized deep neural network (DNN). This approach significantly outperforms traditional classifiers in accuracy, precision, recall, and F1-score. Additionally, our framework enables real-time DDI monitoring, which is particularly valuable in COVID-19 patient care. The model’s success in accurately predicting adverse effects demonstrates the potential of deep learning to enhance drug safety and support personalized medicine, paving the way for safer, data-driven treatment strategies.

The article undertakes an exploration into the rather unexpected progressiveness exhibited by courts across the globe in bestowing protection upon LGBTQ rights. A three-pronged study, which encompasses an examination of the theoretical rationales, empirical investigations, and doctrinal underpinnings of the augmentation of LGBTQ rights in diverse locales, is executed. It is hypothesized that a prima facie paradox emerges, whereby LGBTQ rights have been safeguarded and advanced in an extraordinary fashion, while concurrently, a discernible general trend of deviation from liberal constitutionalism, rights safeguarding mechanisms, and the rule of law is observable in other arenas. This article scrutinizes this contention and discovers that it is substantiated by case law from various regions. Critical theory and Butler’s theory of performativity potentially offer the most cogent explanations for this paradox. They have led to the social embrace of LGBTQ rights, while simultaneously, the enactment or amplification of these rights even in illiberal states furnishes an effortless ‘triumph’ for illiberal political actors, which can be employed as a countermeasure against assaults on their liberal and democratic reputations.

Hospital waste containing antibiotics is toxic to the ecosystem. Ciprofloxacin is one of the essential, widely used antibiotics and is often detected in water bodies and soil. It is vital to treat these medical wastes, which urge new research towards waste management practices in hospital environments themselves. Ultimately minimizes its impact in the ecosystem and prevents the spread of antibiotic resistance. The present study highlights the decomposition of ciprofloxacin using nano-catalytic ZnO materials by reactive oxygen species (ROS) process. The most effective process to treat the residual antibiotics by the photocatalytic degradation mechanism is explored in this paper. The traditional co-precipitation method was used to prepare zinc oxide nanomaterials. The characterization methods, X-Ray diffraction analysis (XRD), Fourier Transform infrared spectroscopy (FTIR), Ulraviolet-Visible spectroscopy (UV-Vis), Scanning Electron microscopy (SEM) and X-Ray photoelectron spectroscopy (XPS) have done to improve the photocatalytic activity of ZnO materials. The mitigation of ciprofloxacin catalyzed by ZnO nano-photocatalyst was described by pseudo-first-order kinetics and chemical oxygen demand (COD) analysis. In addition, ZnO materials help to prevent bacterial species, S. aureus and E. coli, growth in the environment. This work provides some new insights towards ciprofloxacin degradation in efficient ways.

Medicinal herbs have been extensively utilized in the remediation of various health conditions. Dialium guineense fruit pulp, also well known as Velvet Tamarind is widely consumed in West Africa for its dietary and medicinal properties. The study aims to analyze the phytochemical constituents, vitamin content and the in vitro antioxidant effect of Dialium guineense fruit pulp (DGFP). The phytochemical constituents, vitamins (C, E, B1-12) composition, and in vitro antioxidant activity were examined utilizing standardized analytical methods. The qualitative and quantitative phytochemical screening of the fruit pulp of Dialium guineense was also carried out; the result indicated the presence of flavonoids, alkaloids, saponins, tannins, terpenoids, phenols, steroids, and cardiac glycosides in varying concentrations. The vitamin composition revealed that vitamin C was higher than other vitamins in the fruit pulp. The DPPH (2,2-diphenyl-1-picrylhydrazyl) and nitric oxide scavenging assay showed high radical scavenging activity while the FRAP (Ferric reducing antioxidant power) assay revealed significant reducing power. This indicates that Dialium guineense fruit pulp has potential health benefits.

We develop a relatively cheap technology of processing a scrap in the form of already used tungsten-containing products (spirals, plates, wires, rods, etc.), as well not conditional tungsten powders. The main stages of the proposed W-scrap recycling method are its dispersing and subsequent dissolution under controlled conditions in hydrogen peroxide aqueous solution resulting in the PTA (PeroxpolyTungstic Acid) formation. The filtered solution, as well as the solid acid obtained by its evaporation, are used to synthesize various tungsten compounds and composites. Good solubility of PTA in water and some other solvents allows preparing homogeneous liquid charges, heat treatment of which yield WC and WC–Co in form of ultradispersed powders. GO (Graphene Oxide) and PTA composite is obtained and its phase transition in vacuum and reducing atmosphere (H₂) is studied. By vacuum-thermal exfoliation of GO–PTA composite at 170–500℃ the rGO (reduced GO) and WO_2.9 tungsten oxide are obtained, and at 700℃—rGO–WO₂ composite. WC, W₂C and WC–Co are obtained from PTA at high temperature (900–1000℃). By reducing PTA in a hydrogen atmosphere, metallic tungsten powder is obtained, which was used to obtain sandwich composites with boron carbide B₄C, W/B₄C, and W/(B₄C–W), as neutron shield materials. Composites of sandwich morphology are formed by SPS (Spark-Plasma Sintering) method.