Objective: To investigate the value of differential diagnosis of hepatocellular carcinoma (HCC) and cirrhotic nodules via radiomics models based on magnetic resonance images. Background: This study is to distinguish hepatocellular carcinoma and cirrhotic nodules using MR-radiomics features extracted from four different phases of MRI images, concluded T1WI, T2WI, T2 SPIR and delay phase of contrast MRI. Methods: In this study, the four kind of magnetic resonance images of 23 patients with hepatocellular carcinoma (HCC) were collected. Among them, 12 patients with liver cirrhosis were used to obtain cirrhotic nodules (CN). The dataset was used to extract MR-radiomics features from regions of interest (ROI). The statistical methods of MRradiomics features could distinguish HCC and CN. And the ability of radiomics features between HCC and CN was estimated by receiver operating characteristic curve (ROC). Results: A total of 424 radiomics features were extracted from four kind of magnetic resonance images. 86 features in delay phase of contrast MRI，86 features in spir phase of T2WI，86 features in T1WI and 88 features in T2WI showed statistical difference (p < 0.05). Among them, the area under the curves (AUC) of these features larger than 0.85 were 58 features in delay phase of contrast MRI, 54 features in spir phase of T2WI, 62 features in T1WI and 57 features in T2WI. Conclusions: Radiomics features extracted from MRI images have the potential to distinguish HCC and CN.

The H3N2 influenza virus is spiking dramatically, which is a major concern worldwide and in India. The multifunctional hetero-trimer influenza virus RNA-dependent RNA polymerase (RdRP) is involved in the generation of viral mRNA and is crucial for viral infectivity, which is directly related to the virus’s ability to survive. The goal of the current work was to use molecular docking to determine how the RdRP protein might be affected by powerful bioactive chemicals found in Calotropis gigantia latex. By applying CB-dock 2 analysis and 2D interactions, an in-silico docking study was conducted using a GC-FID (gas chromatography with flame-ionization detection) based composition profile. Tocospiro A (15%), Amyrin (7%), and Gombasterol A were found by GC-FID to be the main phytocompounds in the latex of Calotropis gigantia. The docking result showed that ligands were effectively bound to RdRP. According to interaction studies, RdRP/ligand complexes create hydrogen bonds, van der Waals forces, pi-alkyl bonds, alkyl bonds, and pi-Sigma bonds. Therefore, it was suggested that Calotropis gigantia latex may represent a possible herbal remedy to attenuate H3N2 infections based on the above findings of the fragrance profile and docking.

This research study explores the addition of chromium (Cr⁶⁺) ions as a nucleating agent in the alumino-silicate-glass (ASG) system (i.e., Al₂O₃-SiO₂-MgO-B₂O₃-K₂O-F). The important feature of this study is the induction of nucleation/crystallization in the base glass matrix on addition of Cr⁶⁺ content under annealing heat treatment (600 ± 10 °C) only. The melt-quenched glass is found to be amorphous, which in the presence of Cr⁶⁺ ions became crystalline with a predominant crystalline phase, Spinel (MgCr₂O₄). Microstructural experiment revealed the development of 200–500 nm crystallite particles in Cr⁶⁺-doped glass-ceramic matrix, and such type microstructure governed the mechanical properties. The machinability of the Cr-doped glass-ceramic was thereby higher compared to base alumino-silicate glass (ASG). From the nano-indentation experiment, the Young’s modulus was estimated 25(±10) GPa for base glass and increased to 894(±21) GPa for Cr-doped glass ceramics. Similarly, the microhardness for the base glass was 0.6(±0.5) GPa (nano-indentation measurements) and 3.63(±0.18) GPa (micro-indentation measurements). And that found increased to 8.4(±2.3) (nano-indentation measurements) and 3.94(±0.20) GPa (micro-indentation measurements) for Cr-containing glass ceramic.