The fast-growing field of nanotheranostics is revolutionizing cancer treatment by allowing for precise diagnosis and targeted therapy at the cellular and molecular levels. These nanoscale platforms provide considerable benefits in oncology, including improved disease and therapy specificity, lower systemic toxicity, and real-time monitoring of therapeutic outcomes. However, nanoparticles' complicated interactions with biological systems, notably the immune system, present significant obstacles for clinical translation. While certain nanoparticles can elicit favorable anti-tumor immune responses, others cause immunotoxicity, including complement activation-related pseudoallergy (CARPA), cytokine storms, chronic inflammation, and organ damage. Traditional toxicity evaluation approaches are frequently time-consuming, expensive, and insufficient to capture these intricate nanoparticle-biological interactions. Artificial intelligence (AI) and machine learning (ML) have emerged as transformational solutions to these problems. This paper summarizes current achievements in nanotheranostics for cancer, delves into the causes of nanoparticle-induced immunotoxicity, and demonstrates how AI/ML may help anticipate and create safer nanoparticles. Integrating AI/ML with modern computational approaches allows for the detection of potentially dangerous nanoparticle qualities, guides the optimization of physicochemical features, and speeds up the development of immune-compatible nanotheranostics suited to individual patients. The combination of nanotechnology with AI/ML has the potential to completely realize the therapeutic promise of nanotheranostics while assuring patient safety in the age of precision medicine.

This paper examines the transformative potential of e-government in public administration, focusing on its capacity to enhance service delivery, transparency, accessibility, cost efficiency, and civic engagement. The study identifies key challenges, including inadequate technological infrastructure, cybersecurity vulnerabilities, resistance to change within public institutions, and a lack of public awareness about e-government services. These barriers hinder the seamless operation and adoption of digital government initiatives. Conversely, the study highlights significant opportunities such as streamlined service delivery, enhanced transparency through real-time access to government data, increased accessibility for marginalized and remote communities, substantial cost savings, and greater civic engagement via digital platforms. Addressing these challenges through targeted strategies—enhancing technological infrastructure, bolstering cybersecurity, managing organizational change, and raising public awareness—can help policymakers and public administrators implement more effective and inclusive e-government initiatives. Additionally, the integration of these digital solutions can drive sustainable development and digital inclusion, fostering social equity and economic growth. By leveraging these opportunities, governments can achieve more efficient, transparent, and accountable governance. Ultimately, the successful implementation of e-government can transform the relationship between citizens and the state, building trust and fostering a more participatory democratic process.

The efficiencies and performance of gas turbine cycles are highly dependent on parameters such as the turbine inlet temperature (TIT), compressor inlet temperature (T1), and pressure ratio (Rc). This study analyzed the effects of these parameters on the energy efficiency, exergy efficiency, and specific fuel consumption (SFC) of a simple gas turbine cycle. The analysis found that increasing the TIT leads to higher efficiencies and lower SFC, while increasing the To or Rc results in lower efficiencies and higher SFC. For a TIT of 1400 ℃, T1 of 20 ℃, and Rc of 8, the energy and exergy efficiencies were 32.75% and 30.9%, respectively, with an SFC of 187.9 g/kWh. However, for a TIT of 900 ℃, T1 of 30 ℃, and Rc of 30, the energy and exergy efficiencies dropped to 13.18% and 12.44%, respectively, while the SFC increased to 570.3 g/kWh. The results show that there are optimal combinations of TIT, To, and Rc that maximize performance for a given application. Designers must consider trade-offs between efficiency, emissions, cost, and other factors to optimize gas turbine cycles. Overall, this study provides data and insights to improve the design and operation of simple gas turbine cycles.

This study explores the impact of online assessments on students’ academic performance and learning outcomes at the University of Technology in South Africa. The research problem addresses the effectiveness and challenges of digital assessment platforms in higher education (HE), particularly their influence on student engagement, feedback quality, and academic integrity. A qualitative case study approach was employed, involving semi-structured interviews with ten undergraduate and postgraduate students from diverse academic backgrounds. The findings reveal that while online assessments provide flexibility and immediate feedback, they also pose challenges related to technical issues, feedback delays, and concerns about long-term knowledge retention. The study highlights the necessity of aligning assessment strategies with constructivist learning principles to enhance critical thinking and student-centered learning. Implications for theory include strengthening the application of constructivist learning in digital environments, while practical recommendations focus on improving assessment design, institutional support, and feedback mechanisms. Policy adjustments should consider inclusive and equitable access to online assessments. Future research should further investigate the long-term impact of digital assessments on professional readiness. This study contributes to ongoing discussions on online education by offering a nuanced understanding of digital assessment challenges and opportunities in higher education.

This systematic literature review (SLR) delves into the realm of Artificial Intelligence (AI)-powered virtual influencers (VIs) in social media, examining trust factors, engagement strategies, VI efficacy compared to human influencers, ethical considerations, and future trends. Analyzing 60 academic articles from 2012 to 2024, drawn from reputable databases, the study applies specific inclusion and exclusion criteria. Both automated and manual searches ensure a comprehensive review. Findings reveal a surge in VI research post-2012, primarily in journals, with quantitative methods prevailing. Geographically, research focuses on Europe, Asia Pacific, and North America, indicating gaps in representation from other regions. Key themes highlight trust and engagement’s critical role in VI marketing, navigating the balance between consistency and authenticity. Challenges persist regarding artificiality and accountability, managed through brand alignment and transparent communication. VIs offers advantages, including control and cost efficiencies, yet grapple with authenticity issues, addressed through human-like features. Ethically, VI emergence demands stringent guidelines and industry cooperation to safeguard consumer well-being. Looking ahead, VIs promises transformative storytelling, necessitating vigilance in ethical considerations. This study advocates for continued scholarly inquiry and industry reflection to navigate VI marketing evolution responsibly, shaping the future influencer marketing landscape.

This study explores the intricate relationship between family functioning, emotional bonding, parent-child contact, and academic success among students through a serial mediation analysis. The research, conducted on a sample of 200 participants, sheds light on the indirect pathways through which family dynamics influence academic achievements, emphasizing the significance of emotional connections and parent-child interactions. The findings affirm the positive association between family functioning and academic achievement, in alignment with prior research. Additionally, the study identifies parent-child bonds and contact as partial mediators in this relationship, reinforcing previous findings. A noteworthy discovery is the full complementary sequential mediation effect, revealing that family functioning’s influence on academic success becomes substantial when emotional bonds foster increased parent-child contact. In conclusion, this research underscores the importance of emotional bonds and parent-child contact as sequential mediators, emphasizing their role in translating family dynamics into academic achievements among students. While providing valuable insights, the study acknowledges limitations such as sample size, potential sampling bias, self-reported measures, and a cross-sectional design. Addressing these limitations and expanding the scope of outcomes in future research will contribute to a more comprehensive understanding of the complex dynamics within family and educational institutions relationships and their profound impacts on students’ academic success.