The MDA-MB-231 cell line is derived from triple-negative breast cancer (TNBC), representing one of the most aggressive forms of breast cancer. Innovative therapeutic strategies, including s targeted therapies using nanocarriers, hold significant promise, particularly for difficult-to-treat cancers such as TNBC. Nanoparticles have transformed the medical field by serving as advanced drug delivery systems for cancer treatment. They play a critical role in overcoming the drug resistance often associated with cancer therapies. When utilized as drug delivery vehicles, nanoparticles can specifically target cancer cells and effectively reduce or eliminate multidrug resistance. Among them, chitosan-coated magnetic nanoparticles (MNPs) have been widely explored for the loading and controlled release of various anticancer agents. In this study, we evaluated the effects of dexamethasone-loaded chitosan-coated MNPs on MDA-MB-231 cell lines. Fourier transform infrared spectroscopy and scanning electron microscopy were employed to verify the successful loading of dexamethasone onto the nanoparticles. To assess cytotoxicity, empty nanoparticles, free drug, and drug-loaded nanoparticles were tested on the cells. The results indicated that empty nanoparticles exhibited no toxic effects. The IC50 value of the free drug was 123 µg/mL, while the IC50 value of the drug-loaded nanoparticles was significantly lower, at 63 µg/mL. These findings confirmed the successful conjugation of dexamethasone to the chitosan-coated MNPs, demonstrating substantial cytotoxic effects on breast cancer cells. Although dexamethasone has been reported to exhibit both tumor-suppressive and pro-metastatic effects, its specific impact on TNBC warrants further investigation in future studies.

Farm households in developing countries are often involved in a variety of livelihood income-generating activities to achieve basic needs and enhance food security. However, little attention has been given to investigating the effect of livelihood diversification strategies on the adoption of agricultural land management practices. This study explored the nexus between livelihood diversification and Agricultural Land Management (ALM) practices in the Southern Ethiopian Highlands. Data for this study were gathered through a structured questionnaire, interviews, and focus group discussions. A total of 423 sample respondents were selected by using multistage random sampling techniques. The data were analyzed using the Inverse Herfindahl Hirschman Diversity Index (IHHDI), the multinomial logit model (MNL), and the probit regression model. The findings of the study revealed that on-farm income activities are the most dominant livelihood income strategies (69.1%), followed by non-farm (21%) and off-farm (9.64%). The multinomial logit model analysis demonstrated that variables such as sex, education, family size, distance to market, land size, extension contact, membership in cooperatives, and household income were the major drivers of farmers income diversification activities (p<0.05). The results of the probit analysis indicated that income from crop production, daily labor work, rents from farmland, and farm assets have a positive and significant effect on households' decisions to implement ALM practices. In contrast, incomes from remittance and migrant sources have a negative but statistically significant impact on the adoption of ALM measures. The farm household sources of income-generating strategies substantially affected the adoption intensity of ALM measures. Income generated from the on-farm sector alone cannot be considered a core income-generating activity for households or a means of achieving food security. Therefore, land management policies and program implementations should consider farmers’ livelihood diversification and income-generating strategies. In addition, such interventions need to promote sustainable farming practices, enhance innovation, and related measures for the adoption of ALM measures to ensure land sustainability.

The debate on the effect of work environment on job satisfaction is very inconclusive. Most of the existing literature has focused on either the developed economy or job satisfaction and other variables other than the dimensions of the work environment. To fill the contextual and conceptual gap this study examined the effect of dimensions of work environment on job satisfaction among public sector workers in a developing economy. The study used the quantitative method and positivist philosophical viewpoint but specifically, the explanatory design was used to guide the study. A structured questionnaire was used for data collection and data analysis was done by partial least square modelling. The study found that the three dimensions of work environment such as physical, psychological and administrative work environment had a significant relationship with job satisfaction among public workers in a developing economy. It was recommended that the management of public sector organisations should improve upon the psychological, physical and administrative work environment to ensure job satisfaction among their workers. 

The widespread adoption of digital technologies in tourism has transformed the data privacy landscape, necessitating stronger safeguards. This study examines the evolving research environment of digital privacy in tourism management, focusing on publication trends, collaborative networks, and social contract theory. A mixed-methods approach was employed, combining bibliometric analysis, social contract theory, and qualitative content analysis. Data from 2004 to 2023 were analyzed using network visualization tools to identify key researchers and trends. The study highlights a significant increase in academic attention after 2015, reflecting the industry's growing recognition of digital privacy as crucial. Social contract theory provided a framework emphasizing transparency, consent, and accountability. The study also examined high-impact articles and the role of publishers like Elsevier and Wiley. The findings offer practical insights for policymakers, industry leaders, and researchers, advocating for ongoing collaboration to address privacy challenges in tourism.

Over 90% of cancer-related mortality worldwide is due to metastatic disease since the dynamic tumor microenvironment poses huge challenges in preventing the spread of metastatic cancer. Introducing the advent of advance biomaterials and their swift evolution, this review highlights the great potential of innovative biomaterials to proficiently tackle the metastatic tumor environment. Focusing on four distinct categories of biomaterials systems, action mechanism of biomaterials utilized in anti-tumor therapy is explained in detail: 1. Nanoplatforms sensitive to biochemical cues including pH, redox, and enzymes are known as stimuli-responsive nanoplatforms that react according their environment, 2. Smart nanoplatforms changing their morphology to penetrate impermeable physical barriers at tumor site, 3. Ingenious biomaterial participating in tumor normalization, and 4. Nanoplatforms with real-time theranostic capabilities due to innate feedback-loop mechanism. Ingeniously structured biomaterials with extensive evidence in preclinical efficacy encourage their inclusion in metastatic tumor therapy however, their utilization in medical settings is prevented due to various challenges; impractical manufacturing cost, regulatory and safety issues as well as large-scale production are major challenges restraining their widespread use. A concrete framework is proposed in this review to accelerate the biomaterial structure standardization process, following the GMP and other regulatory guidelines with the aim of implementing biomaterial-based tumor diagnostics and therapies. Since incorporating advancing technologies in tumor therapy such AI-driven, autonomous biomaterial structure or patient-specific tumor models would enable confront the proliferating metastatic tumor cases.