The present work shows an application of the Chan-Vese algorithm for the semi-automatic segmentation of anatomical structures of interest (lungs and lung tumor) in 4DCT images of the thorax, as well as their three-dimensional reconstruction. The segmentation and reconstruction were performed on 10 CT images, which make up an inspiration-expiration cycle. The maximum displacement was calculated for the case of the lung tumor using the reconstructions of the onset of inspiration, the onset of expiration, and the voxel information. The proposed method achieves appropriate segmentation of the studied structures regardless of their size and shape. The three-dimensional reconstruction allows us to visualize the dynamics of the structures of interest throughout the respiratory cycle. In the future, it is expected to have more evidence of the good performance of the proposed method and to have the feedback of the clinical expert, since the knowledge of the characteristics of anatomical structures, such as their dimension and spatial position, helps in the planning of Radiotherapy (RT) treatments, optimizing the radiation dose to cancer cells and minimizing it in healthy organs. Therefore, the information found in this work may be of interest for the planning of RT treatments.

The suspicion of mediastinal alterations, always includes in its initial study, the chest radiography. The identification of mediastinal alterations in the X-ray is a priority. The knowledge of the mediastinal references and the identification of their alterations allows the suspicion of a pathology specific to each of the mediastinal spaces. When the semiology of mediastinal lesions, their location and the three most frequent pathologies are taken into account, the possibility of having an etiological diagnosis increases^[1]. This is a review article based on a detailed literature search, in which radiological mediastinal references are studied, with emphasis on the epidemiological data of each one of them.

The effect of isocyanate trimer on the flame retardancy mechanism of polyisocyanurate (PIR) foam was studied in three aspects, including the mechanism of thermal decomposition in the condensed phase, the barrier mechanism of carbon layer formation on the surface in the condensed phase, and the mechanism in the gaseous phase, by using infrared spectroscopy, scanning electron microscopy, thermal analysis, a cone calorimeter, and high-temperature pyrolysis gas chromatography mass spectrometry. The results show that the trimmer can improve the thermal stability of the PIR foam and is not easily decomposed in the combustion. The trimmer can increase the carbon content of the PIR foam to 29.9% of that of the polyurethane (PU) foam. The carbon layer formed is denser, and it can retard heat and oxygen and thus improve the flame retardant properties; trimer can reduce the release of flammable polyol gas, decompose into more carbon dioxide, which is an inert gas, and it has certain flame retardant effects in the gaseous phase.

Objective: This study investigates the efficacy and safety of epidural infiltration with drugs and an oxygen-ozone mixture for treating cervicobrachialgia due to disc-radicular conflict or on a degenerative basis, utilizing both retrospective analysis and direct visualization techniques. Methods: A retrospective study involving 10 patients treated with epidural infiltrations of an oxygen-ozone mixture and cortisone was conducted. The procedures were performed under CT guidance to ensure precise delivery and to monitor the diffusion of the injected substances. Pain levels were assessed using the Numerical Rating Scale (NRS) and treatment efficacy was evaluated based on symptom relief and reduction in NSAID intake. Results: Significant pain reduction was observed post-treatment, with median NRS scores decreasing from 9 (baseline) to 2 (follow-up), and a significant decrease in on-demand NSAID intake. Only one minor complication of a headache was reported. The study also demonstrated the ability of ozone to diffuse through the epidural adipose tissue, potentially enhancing treatment efficacy. Conclusion: The combined use of an oxygen-ozone mixture and cortisone for epidural infiltration is an effective and safe treatment for cervicobrachialgia, offering significant pain relief and minimizing the risk associated with traditional epidural injections. This technique presents a viable non-surgical option for patients suffering from disc-radicular conflict or degenerative conditions.

Prepolymers containing isocyanates must be prevented from curing when exposed to moisture, which can be achieved by blocking the isocyanate groups with a suitable agent. The study carefully examines several blocking agents, including methyl ethyl ketoxime (MEKO), caprolactam, and phenol, and concludes that methyl ethyl ketoxime is the best choice. Spectroscopic and thermal analyses, as well as oven curing studies, are conducted with various blocking agents and isocyanate prepolymer to castor oil ratios, revealing MEKO to be the most effective blocking agent which gets unblocked at higher temperatures.

Objectives: The unprecedented COVID-19 pandemic has intensified the stress on blood banks and deprived the blood sources due to the containment measures that restrict the movement and travel limitations among blood donors. During this time, Malaysia had a significant 40% reduction in blood supply. Blood centers and hospitals faced a huge challenge balancing blood demand and collection. The health care systems need a proactive plan to withstand the uncertain situation such as the COVID-19 pandemic. This study investigates the psychosocial factors that affect blood donation behavior during a pandemic and aims to propose evidence-based strategies for a sustainable blood supply. Study design: Qualitative design using focus group discussion (FGD) was employed. Methods: Data were acquired from the two FGDs that group from transfusion medicine specialists (N = 8) and donors (N = 10). The FGD interview protocol was developed based on the UTM Research Ethics Committee’s approval. Then, the data was analyzed using Nvivo based on the General Inductive Approach (GIA). Results: Analysis of the text data found that the psychology of blood donation during the pandemic in Malaysia can be classified into four main themes: (i) reduced donation; (ii) motivation of donating blood; (iii) trends of donation; and (iv) challenges faced by the one-off, occasional, and non-donors. Conclusions: Based on the emerging themes from the FGDs, this study proposes four psycho-contextual strategies for relevant authorities to manage sustainable blood accumulation during the pandemic: (1) develop standard operating procedure for blood donors; (2) organize awareness campaigns; (3) create a centralized integrated blood donors database; and (4) provide innovative Blood Donation Facilities.