Clinical/methodological problem: The identification of clinically significant prostate carcinomas while avoiding overdiagnosis of low-malignant tumors is a challenge in routine clinical practice. Standard radiologic procedures: Multiparametric magnetic resonance imaging (MRI) of the prostate acquired and interpreted according to PI-RADS (Prostate Imaging Reporting and Data System Guidelines) is accepted as a clinical standard among urologists and radiologists. Methodological innovations: The PI-RADS guidelines have been newly updated to version 2.1 and, in addition to more precise technical requirements, include individual changes in lesion assessment. Performance: The PI-RADS guidelines have become crucial in the standardization of multiparametric MRI of the prostate and provide templates for structured reporting, facilitating communication with the referring physician. Evaluation: The guidelines, now updated to version 2.1, represent a refinement of the widely used version 2.0. Many aspects of reporting have been clarified, but some previously known limitations remain and require further improvement of the guidelines in future versions.

The rise of internet-based pharmacies has transformed the healthcare sector, giving patients access to medications, information, and direct interaction with pharmacists. While online pharmacies have become popular around the world, there are challenges hindering their widespread use in developing countries due to a limited understanding of the factors affecting their acceptance and usage. To bridge this knowledge gap, a study utilized a model combining the unified theory of acceptance and use of technology (UTAUT 2) with the technology acceptance model (TAM) to explore the drivers behind online pharmacy usage in Oman. Through this framework, twelve hypotheses were. A survey involving 378 individuals familiar with online pharmacies was conducted. Structural equation modeling (SEM) was applied to analyze the data and test these hypotheses. The results indicate that factors such as perceived expectancy effort expectancy and facilitating conditions hedonic motivation, habit perceived risk, technology trust, and technology awareness play roles in influencing the adoption of online pharmacies in Oman. The findings suggest that personal innovation plays a moderating role in the connection between perceived risk and behavioral intention, while it has a negative moderating influence on the relationship between technology trust and behavioral intention. Word of mouth was identified as a moderator in enhancing the correlation between behavioral intention and online pharmacy adoption. This research emphasizes the moderating relationship of personal innovation and word of mouth on shaping consumer attitudes towards online pharmacies and their acceptance. In summary, these results add to the existing knowledge on pharmacy adoption and in developed areas such as provide practical insights for online pharmacy providers to improve their offerings and attract a larger customer base.

The study explores improving opportunities of forecasting accuracy from the traditional method through advanced forecasting techniques. This enables companies to optimize inventory management, production planning, and reducing the travelling time thorough vehicle route optimization. The article introduced a holistic framework by deploying advanced demand forecasting techniques i.e., AutoRegressive Integrated Moving Average (ARIMA) and Recurrent Neural Network-Long Short-Term Memory (RNN-LSTM) models, and the Vehicle Routing Problem with Time Windows (VRPTW) approach. The actual milk demand data came from the company and two forecasting models, ARIMA and RNN-LSTM, have been deployed using Python Jupyter notebook and compared them in terms of various precision measures. VRPTW established not only the optimal routes for a fleet of six vehicles but also tactical scheduling which contributes to a streamlined and agile raw milk collection process, ensuring a harmonious and resource-efficient operation. The proposed approach succeeded on dropping about 16% of total travel time and capable of making predictions with approximately 2% increased accuracy than before.

We develop a relatively cheap technology of processing a scrap in the form of already used tungsten-containing products (spirals, plates, wires, rods, etc.), as well not conditional tungsten powders. The main stages of the proposed W-scrap recycling method are its dispersing and subsequent dissolution under controlled conditions in hydrogen peroxide aqueous solution resulting in the PTA (PeroxpolyTungstic Acid) formation. The filtered solution, as well as the solid acid obtained by its evaporation, are used to synthesize various tungsten compounds and composites. Good solubility of PTA in water and some other solvents allows preparing homogeneous liquid charges, heat treatment of which yield WC and WC–Co in form of ultradispersed powders. GO (Graphene Oxide) and PTA composite is obtained and its phase transition in vacuum and reducing atmosphere (H₂) is studied. By vacuum-thermal exfoliation of GO–PTA composite at 170–500℃ the rGO (reduced GO) and WO_2.9 tungsten oxide are obtained, and at 700℃—rGO–WO₂ composite. WC, W₂C and WC–Co are obtained from PTA at high temperature (900–1000℃). By reducing PTA in a hydrogen atmosphere, metallic tungsten powder is obtained, which was used to obtain sandwich composites with boron carbide B₄C, W/B₄C, and W/(B₄C–W), as neutron shield materials. Composites of sandwich morphology are formed by SPS (Spark-Plasma Sintering) method.

Paraffin wax is the most common phase change material (PCM) that has been broadly studied, leading to a reliable optimal for thermal energy storage in solar energy applications. The main advantages of paraffin are its high latent heat of fusion and low melting point that appropriate solar thermal energy application. In addition to its accessibility, ease of use, and ability to be stored at room temperature for extended periods of time, Nevertheless, improving its low thermal conductivity is still a big, noticeable challenge in recently published work. In this work, the effect of adding nano-Cu₂O, nano-Al₂O₃ and hybrid nano-Cu₂O-Al₂O₃ (1:1) at different mass concentrations (1, 3, and 5 wt%) on the thermal characteristics of paraffin wax is investigated. The measured results showed that the peak values of thermal conductivity and diffusivity are achieved at a wight concentration of 3% when nano-Cu₂O and nano-Al₂O₃ are added to paraffin wax with significant superiority for nano-Cu₂O. While both of those thermal properties are negatively affected by increasing the concentration beyond this value. The results also showed the excellence of the proposed hybrid nanoparticles compared to nano-Cu₂O and nano-Al₂O₃ as they achieve the highest values of thermal conductivity and diffusivity at a weight concentration of 5.0 wt%.

This review focuses on ferrites, which are gaining popularity with their unique properties like high electrical resistivity, thermal stability, and chemical stability, making them suitable for versatile applications both in industry and in biomedicine. This review is highly indicative of the importance of synthesis technique in order to control ferrite properties and, consequently, their specific applications. While synthesizing the materials with consideration of certain properties that help in certain methods of preparation using polyol route, green synthesis, sol-gel combustion, or other wise to tailor make certain properties shown by ferrites, this study also covers biomedical applications of ferrites, including magnetic resonance imaging (MRI), drug delivery systems, cancer hyperthermia therapy, and antimicrobial agents. This was able to inhibit the growth of all tested Gram-negative and positive bacteria as compared with pure ferrite nanoparticles without Co, Mn or Zn doping. In addition, ferrites possess the ability to be used in environmental remediation; such as treatment of wastewater which makes them useful for high-surface-area and adsorption capacity due heavy metals and organic pollutants. A critical analysis of functionalization strategies and possible applications are presented in this work to emphasize the capability of nanoferrites as an aid for the advancement both biomedical technology and environmental sustainability due to their versatile properties combined with a simple, cost effective synthetic methodology.